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5 edition of Interactions Between the Stroma and Thyroid Epithelial Cells of Normal and Malignant Origin found in the catalog.

Interactions Between the Stroma and Thyroid Epithelial Cells of Normal and Malignant Origin

Therese Dahlman

Interactions Between the Stroma and Thyroid Epithelial Cells of Normal and Malignant Origin

  • 176 Want to read
  • 26 Currently reading

Published by Uppsala Universitet .
Written in English

  • Physiology,
  • Medical

  • Edition Notes

    SeriesComprehensive Summaries of Uppsala Dissertations, 861
    The Physical Object
    ID Numbers
    Open LibraryOL12854111M
    ISBN 109155445217
    ISBN 109789155445218

      The reciprocal interaction between epithelial and stromal cells plays a key role in the morphogenesis, proliferation and differentiation of epithelial cells (31–33). Most of the intercellular substances, extracellular matrix (ECM) molecules that are required for tumour growth and progression are produced by the stromal cells (34).Cited by: Learn malignant biology with free interactive flashcards. Choose from 74 different sets of malignant biology flashcards on Quizlet. stroma of thyroid gland: the connective tissue that supports the lobules and follicles of the thyroid gland. Synonym(s): stroma glandulae thyroideae.   This reaction of SCs may be a result of separated single cell-type culturing in a 2D cell culture system due to a lack of interactions between stromal and epithelial cells. Haslam et al. demonstrated that in the mammary gland oestrogenic effects on glandular epithelial cells are controlled by mammary stromal cells in vivo and in by: 7.

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Interactions Between the Stroma and Thyroid Epithelial Cells of Normal and Malignant Origin by Therese Dahlman Download PDF EPUB FB2

Endocrine and locally produced factors as well as interactions between epithelial cells and the stroma important in the control of growth and function of the thyroid gland. In this study, the effects of, and mechanism(s) for, such cross-talk under some normal and pathological conditions were investigated.

In this study, a co-culture model containing epithelial and stromal cells was used to investigate the interactions of these cells in macromastia. Epithelial cell proliferation and branching morphogenesis were measured to assess the effect of macromastic stromal cells on epithelial by: 8.

Interactions between the stroma and thyroid epithelial cells of normal and malignant origin Dahlman, Thérèse Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.

The interaction between stroma and epithelium can either result in a protective outcome or in malignant transformation. So, epithelial stem cell malignant transformation is Cited by: 4.

Interactions between stroma and epithelia in the normal and malignant prostatic microenvironment involve a number of soluble factors and their receptors. Soluble factors act in paracrine fashion by binding to their respective by: The biological and clinical significance of stromal-epithelial interactions in breast cancer Article (PDF Available) in Pathology 49(2) December with 84 Reads How we measure 'reads'.

Stromal–epithelial cell interactions and alteration of branching morphogenesis in macromastic mammary Available via license: CC BY Content may be subject to copyright.

Tumor-stroma interactions at different stages of keratinocyte transformation To determine the alterations that occur in epithelial- stromal interactions during the transformation process in pre-malignant and malignant epithelial tumors, a family of cell lines of transformed human keratinocytes was by: Concluding Remarks In the foregoing sections various modes of interaction between malignant cells and stroma have been described: Malignant cells Interactions Between the Stroma and Thyroid Epithelial Cells of Normal and Malignant Origin book been shown to produce various lytic enzymes, which attack the stroma or to induce fibroblasts to synthesize collagenolytic, elastolytic, and glycosaminoglycan-degrading enzymes (Sections II,B-F J,K).Cited by:   Thyroid nodules can be hyperplastic benign adenomas or malignant lesions, and can be derived from thyroid follicular epithelial cells or C cells ().Cancers that arise in the thyroid.

The leading role of epithelial-stromal dialogue in the development of the mammary gland has been well recognized, but accumulating evidence has demonstrated that in breast cancer altered Interactions Between the Stroma and Thyroid Epithelial Cells of Normal and Malignant Origin book occurring between epithelial malignant cells and the associated fibroblasts play a major part in tumor development, Interactions Between the Stroma and Thyroid Epithelial Cells of Normal and Malignant Origin book and progression –.Cited by: The interaction between HA and cells is mediated by different cell surface receptors, among which CD44 is the most prominent one on melanoma cells.

Furthermore, CD44 interacts with a wide variety of different proteins, including osteopontin, collagen, fibronectin, growth factors, cytokines, and chemokines, as well as metalloproteinases. Tumor Stroma in Anaplastic Thyroid Carcinoma Interstitial Collagen and Cancers are classified according to the tissue and cell type of origin.

Cancers from epithelial cells are termed carcinomas and mesenchymal malignancies are termed matrix (ECM) and carcinoma cells – stroma interactions provide reciprocal influences, which result in.

It is notable that, although the average intensity for each category of normal and malignant endometrium is shown in Fig. 6(A) and 6(B), there was a wide range of patient variability of PEDF immunostaining for nearly all categories of patient tissues for both the epithelial and stromal cells of the endometrium; the epithelial cells show the Cited by: 6.

The study of cancer biology has mainly focused on malignant epithelial cancer cells, although tumors also contain a stromal compartment, which is composed of stem cells, tumor-associated fibroblasts (TAFs), endothelial cells, immune cells, adipocytes, cytokines, and various types of macromolecules comprising the extracellular matrix (ECM).

The tumor stroma develops gradually in response to the Cited by: There is strong association between inflammatory processes and their main metabolic mediators, such as leptin, adiponectin secretion, and low/high-density lipoproteins, with the cancer risk and aggressive behavior of solid tumors.

In this scenario, cancer cells (CCs) and cancer stem cells (CSCs) have important roles. These cellular populations, which come from differentiated cells and Cited by: 4. Solid tumors have a distinct structure that mimics that of normal tissues and comprises two distinct but interdependent compartments: the parenchyma (neoplastic cells) and the stroma that the neoplastic cells induce and in which they are dispersed.

2–4 In many tumors, including those of epithelial cell origin, a basal lamina separates clumps of tumor cells from stroma. However, the basal lamina is often incomplete, especially at points of tumor Cited by: 5.

Both normal and malignant epithelial ovarian cells also produce IL-1, although activated immune cells in the stroma remain the major source of IL Constitutive production of IL-1 β by ovarian carcinoma cells [ 95 ] enhances their invasion capacities by increasing expression of MMP-1 [ 36 ] and stimulating production of proangiogenic factors such as vascular endothelial growth factor (VEGF) [ Cited by: 6.

Genes and gene sets induced in the tumor stroma. (a) Hierarchical cluster analysis of tumor cell, tumor stroma and normal stroma samples.A total of genes was differentially expressed between Cited by: Interactions between epithelial and stromal cells are evident in the oviduct (Umezu and Tomooka, ) as well as in the uterus, where they have been extensively studied in human models for.

Carcinoma cells, like normal epithelial cells, live in a complex microenvironment that includes the extracellular matrix (ECM), diffusible growth factors and cytokines, and a variety of non.

A carcinoma is a malignant tumor of epithelial origin. It is characterized by a marked proliferation of epithelium with infiltration into the surrounding tissues.

The epithelium is arranged atypically in a supporting framework made up of adult connective tissue. Galectin-3, a beta-galactoside binding lectin, is highly expressed in thyroid carcinomas of follicular cell origin, whereas neither benign thyroid adenomas nor normal thyroid tissues express.

Stromal cells are connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow, lymph node and the are cells that support the function of the parenchymal cells of that organ.

The most common stromal cells include fibroblasts and term stromal comes from Latin stromat- “bed covering”, and Ancient Greek στρῶμα. The paracrine relationships between the stroma and the epithelium are two-way. The metabolic cooperation model proposed by Chang and Chung [3] between prostate epithelial cells and fibroblasts assumes that testosterone is mainly metabolised in the epithelial compartment to Cited by: 2.

Surface epithelial stromal tumors, the most common neoplasms of the ovary, encompass five distinct subtypes, namely, serous, mucinous, endometrioid, clear cell and transitional cell along with.

Thyroid Follicular Epithelial Cell Lesions Los Angeles Society of Pathologists The 13th Annual Current Topics in Pathology Janu Bruce M. Wenig, M.D. Continuum Health Partners Dept. of Pathology & Laboratory Medicine New York, NY.

Syndecan-1 (CD) is a transmembrane proteoglycan known to be expressed in various normal and malignant tissues. It is of interest because of a possible prognostic role of differential expression in tumors and its role as a target for indatuximab, a monoclonal antibody coupled with a cytotoxic agent.

To comprehensively analyze CD in normal and neoplastic tissues, we used tissue microarrays Author: Simon Kind, Christina Merenkow, Franziska Büscheck, Katharina Möller, David Dum, Viktoria Chirico, A.

stroma. CELLS OF THE STROMA Cells within the stroma include fibroblasts, vascular, glial, smooth muscle, epithelial, and fat cells, and cells of the immune system.

The most widely studied to date are the fibroblasts, immune cells, and the vascular cells, which we will focus on in this review. Fibroblasts Fibroblasts within normal tissue. malignant cells, while the adaptive immune system rather controls the tumour progression.

However, tumours can evade the host immune system via various mechanisms. They shed surface antigens and down-regu-late the expression of molecules necessary for interaction with immune cells.

They also produce and release factorsCited by: Pathology Test 2. STUDY. PLAY. Neoplasms • New and abnormal formation of tissue • Poorly differentiated- have cells that are difficult to recognize as their cell of origin. Degree of Differentiation • Malignant growth of epithelial cells/ skin cells • Flat, scaly epithelial cells.

Stroma (from Greek στρῶμα, meaning 'layer, bed, bed covering') is the part of a tissue or organ with a structural or connective role. It is made up of all the parts without specific functions of the organ - for example, connective tissue, blood vessels, nerves, ducts, of: Connective tissue.

@article{osti_, title = {Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition}, author = {Gudjonsson, Thorarinn and Ronnov-Jessen, Lone and Villadsen, Rene and Rank, Fritz and Bissell, Mina J and Petersen, Ole William}, abstractNote = {The signals that determine the correct.

Neoplastic cells (tumor parenchyma - the functional units of the cell) 2. Reactive stroma (the supportive units of the cell - connective tissue, blood vessels, and cells of the immune system) *the classification of a tumor cell is based mostly on the tumor parenchyma while the growth and spread depend mostly on the stroma*.

Surface epithelial-stromal tumors are a class of ovarian neoplasms that may be benign or malignant. Neoplasms in this group are thought to be derived from the ovarian surface epithelium (modified peritoneum) or from ectopic endometrial or Fallopian tube (tubal) lty: Oncology.

Early B cells adhere to stromal cells through the interactions between the adhesion molecule VLA-4 on the B cells with the ligand fibronectin on stromal cells (Fig.

The earliest contribution by stromal cells is their secretion of SDF-1 (stromal cell derived factor). SDF-1 is a chemokine (also designated CXCL) that binds to its receptor. Thyroid nodules are frequent in general population, found in –7% of people by palpation and 42–67% by ultrasonography (US).

The differential diagnosis ranges from papillary (PC), follicular (FC) and medullary (MC) carcinomas to follicular adenoma (FA) and colloid goitre. Cancer risk in thyroid nodules varies: 5% in masses found by palpation, –15% by US, –% by computed Author: Ilze Fridrihsone, Ilze Strumfa, Boriss Strumfs, Andrejs Vanags, DainisBalodis, Arvids Jakovlevs, Arn.

refers to preinvasion epithelial malignant tumors of glandular or squamous cell origin dictated by interaction between cancer cells and the microenvironments in which they land Help proliferation= normal cells from local bone marrow stem cells are recruited.

Signaling via direct stromal-epithelial contact may be accomplished via interactions between complimentary cell surface adhesion molecules. The importance of stromal-epithelial interactions is reemphasized by several models of carcinogenesis that suggest that perturbations in these interactions may be involved in tumor by: The increased number of these stromal cells in benign lesions, with lesser involvement of malignant tumors, supports the role of myofibroblasts in tumor containment.[] The lack of myofibroblasts contributes to the ability of a malignant tumor to proliferate and spread.

Here we report the generation of monoclonal antibodies against TRAIL pdf its four membrane-bound receptors (TR1–4), which have been used to stain a range of normal and malignant cells Cited by: In normal epithelial tissues, epithelial cells, or parenchymal cells of epithelia, are highly download pdf, polar cells.

These cells are separated from stromal cells by a basement membrane that prevents these cell populations from mixing. A mixture of these cell types is recognized, normally, as a wound, as in the example of a cut to the skin. Fibroadenomas are common ebook breast tumours that display a characteristic pathological morphology, although several ebook and stromal variations exist.

A very rare histological finding is the presence of multinucleated giant cells throughout the stroma of a benign fibroadenoma. Cells of this type, which are more commonly found incidentally within the interlobular stroma of breast.